Fentanyl and the Current State of the Opioid Epidemic

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Fentanyl is a fully synthetic opioid that is 50 to 100 times stronger than morphine. Because of its high potency, it is most commonly used to treat severe pain, particularly after surgery.

Despite how beneficial it has been for those suffering from pain, the drug has had adverse consequences on the opioid epidemic, contributing to the significant increase in opioid-related overdose deaths. According to the National Institute on Drug Abuse, in 2017, 59% of opioid-related overdose deaths involved fentanyl, compared to just 14.3% in 2010.

Overview of the Opioid Epidemic

The United States has been fighting the opioid epidemic for years, with three distinct waves of opioid-related overdose deaths.

Opioid-related Overdose Deaths

Source: Centers for Disease Control and Prevention

 The first surge started in the 1990s with the over-prescription of pain medications.

The second wave occurred in 2010 after law enforcement and the medical community began attempting to control opioid over-prescription, causing those addicted to pain pills to seek alternative options. Subsequently, many opioid users turned to heroin because it is cheaper and easier to access. It is now estimated that 80 percent of people who use heroin previously used prescription opioids.

Current Wave: Synthetic Opioids

The third and current wave of the opioid epidemic started in 2013 with a significant increase in overdose deaths involving synthetic opioids, primarily illicitly produced fentanyl.

According to drugs.com, as little as two to three milligrams of fentanyl can lead to an overdose.

Fentanyl not only carries a great risk of overdose due to its high potency, but its effects also fade quicker than other opioids. As a result, users often take more to sustain its euphoric effects, which increases the risk of overdose.

One of the most dangerous side effects of fentanyl is respiratory depression, which is common during an opioid-related overdose. When a person’s breathing slows or stops, it can decrease the amount of oxygen that reaches the brain. This condition, called hypoxia, can lead to coma, permanent brain damage, or even death.

Most opioid users don’t initially seek out fentanyl, and instead accidentally consume a drug laced with fentanyl. Because it is relatively inexpensive to produce compared to other opioids, many illegal drug producers lace their products, such as cocaine, heroin, methamphetamine, and MDA, with fentanyl to cut costs.

In addition, some producers add fentanyl to make their drugs more addictive in order to keep their customers coming back. As people who purchase these illegal drugs are often unaware their product contains fentanyl, they are at a greater risk for overdose.

How is Fentanyl Addictive?

Like all opioids, fentanyl works by binding to the opioid receptors in the brain to control pain and emotion. After continued use, the user builds tolerance, and their opioid receptors become less sensitive, requiring them to take a larger dose to feel the same effect. Eventually, it may become difficult for a person using opioids to experience pleasure from anything besides the drug.

Fentanyl is significantly stronger than other opioids. After an opioid user is exposed to fentanyl, their brain chemistry is altered, and they may begin to look for even more potent forms of the drug.

How is Illicitly Manufactured Fentanyl Sold?

Fentanyl is often added to other illicit drugs without the dealer or customer’s knowledge. Additionally, it is also sold in different formulations, including as a powder, dropped onto blotting papers, in eye droppers and nasal sprays, or it may be made into pills to look like prescription opioids.

The Future of the Opioid Epidemic

The opioid epidemic is multifaceted, as there are various parties and drug sub-classes involved. The COVID-19 pandemic has only exacerbated existing issues and made it more difficult for those suffering from substance abuse disorder to get help. By understanding the current drivers of the opioid epidemic, including fentanyl, policymakers can begin to implement effective solutions.


ZICOH, A Solution to the Opioid Crisis

ZICOH will utilize a secure database integrated with AI to form a unique software architecture and advanced patented technology, making it the first device of its kind to enable effective communication through the drug supply chain, from drug manufacturers to wholesalers, distributors, pharmacists, providers, physicians, caregivers, and patients. The device can be programmed to dispense the medication dosage amount, type, and frequency to patients according to the health care provider’s orders and delivery schedule. Each of its features helps ensure patient compliance and patient follow-up, consequentially reducing the risk of addiction and overdose.

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