Oral drug delivery is the most common drug delivery mechanism, but over 15 million Americans have a fear of swallowing pills. Taking medications orally means that the treatment has to go through the largely acidic GI tract and the liver first-pass. This suggests a larger minimally effective oral dose is required to achieve optimum bioavailability, potentially leading to a higher risk of side effects.
Several factors influence the strategy for administering prescription drugs through specific drug delivery systems, including drug safety, systemic response, permeability, absorption, potency, efficacy, bioavailability, reactogenicity, pharmacokinetics, cost-effectiveness, and dose-response, among other factors. Among the routes for various drug deliveries, sublingual drug delivery is emerging as highly beneficial and advantageous. Targeted, sublingual drug delivery may provide an alternative to oral drugs while potentially reducing the dosing needed and possibly avoiding or limiting other delivery systems’ adverse side effects. Although a novel dosing concept, sublingual drug application has been clinically studied and is one of the most effective delivery methods for cannabinoids.
TABMELT® is a revolutionary, patented sublingual drug delivery system that will forever change the way patients take medications. The TABMELT® delivery system is a novel, all-natural, non-toxic sublingual drug delivery system that may offer a set-dose drug delivery system that enhances bioavailability and allows patients to dose by dissolving a tablet underneath the tongue.